Neurons via Retrodifferentiation of Human White Blood Cells. Live, Time Lapse Analysis of Leucocyte Conversion into Neurons over 2 Weeks in Culture. Direct reprogramming:
Researchers at the Stanford University School of Medicine, inspired by the work of Shinya Yamanaka, have succeeded in transforming skin cells directly into oligodendrocyte precursor cells (direct lineage reprogramming!), the cells that wrap nerve cells in the insulating myelin sheaths that help nerve signals propagate. This could lead, in principle, to cell therapies for diseases like inherited leukodystrophies and multiple sclerosis, as well as spinal cord injuries and disease modeling.
Scientists at the University of North Carolina at Chapel Hill (UNC) report that for the first time adult stem cells from human intestinal tissue have been isolated. The accomplishment provides a much-needed resource for scientists eager to uncover the true mechanisms of human stem cell biology, they say. It also enables researchers to explore new tactics to treat inflammatory bowel disease or to ameliorate the side effects of chemotherapy and radiation, which often damage the gut.
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